Natural Products

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Natural product
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Paclitaxel (Taxol) is a natural product derived from the Yew tree.[1]
A natural product is a chemical compound or substance produced by a living organism - found in nature that usually has a pharmacological or biological activity for use in pharmaceutical drug discovery and drug design. A natural product can be considered as such even if it can be prepared by total synthesis.
These small molecules provide the source or inspiration for the majority of FDA-approved agents and continue to be one of the major sources of inspiration for drug discovery. In particular, these compounds are important in the treatment of life-threatening conditions.[2] Contents[hide] * 1 Natural sources * 2 Screening of natural products * 2.1 The plant kingdom * 2.2 The microbial world * 2.3 The marine world * 2.4 Animal sources * 2.5 Venoms and toxins * 3 Traditional Medicine * 4 Isolation and purification * 5 Synthesis * 6 See also * 7 References * 8 External links * 9 Further reading |
[edit] Natural sources
Natural products may be extracted from tissues of terrestrial plants, marine organisms or microorganism fermentation broths. A crude (untreated) extract from any one of these sources typically contains novel, structurally diverse chemical compounds, which the natural environment is a rich source of.
Chemical diversity in nature is based on biological and geographical diversity, so researchers travel around the world obtaining samples to analyze and evaluate in drug discovery screens or bioassays. This effort to search for natural products is known as…...

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